She made her film debut with Anurag Kashyap's Raman Raghav 2.0 in 2016. And also signed a three-film deal with Kashyap's production company Phantom Films in July 2016. The film premiered at the Director's Fortnight at Cannes Film festival 2016, where she was nominated by critics for best supporting performance. In early August 2016, she signed two films, Kaalakaandi directed by Akshat Verma and Chef directed by Raja Menon, both starring opposite Saif Ali Khan.In early September 2016, she signed her first Telugu film starring Adivi Sesh.

She also starred as one of the leads in the Amazon Prime original series Made In Heaven.In 2019 she appeared in a pivotal role in Bard of Blood, an Indian fictional spy thriller Netflix web television series based on the 2015 espionage novel of the same name as an intelligence agency operative.

Dhulipala will make her debut in Malayalam cinema with the Geetu Mohandas directorial-feature Moothon alongside Nivin Pauly. She will also be featured in the Dulquer Salmaan starrer Kurup.