Parineeti Chopra made her screen debut in the romantic comedy Ladies vs Ricky Bahl, in a supporting role with Ranveer Singh and Anushka Sharma. Chopra's second release was Habib Faisal's romantic drama Ishaqzaade in which she played a leading role opposite Arjun Kapoor. Chopra next appeared alongside Sushant Singh Rajput and Vaani Kapoor in the romantic comedy-drama Shuddh Desi Romance (2013), her second collaboration with Maneesh Sharma. The film, set in Jaipur, received positive feedback from the critics and Chopra's portrayal of Gayatri, an outspoken and rebellious girl, was particularly praised.
In 2016, Chopra gave a cameo appearance and shot a dance number "Jaaneman Aah" with Varun Dhawan for Rohit Dhawan's directorial Dishoom. After a three-year sabbatical from full-time acting, Chopra returned to screen in 2017 with Yash Raj Films' romantic drama Meri Pyaari Bindu opposite Ayushmann Khurana. She played the titular character, Bindu (an aspiring singer), and made her playback singing debut with two versions of the song Maana Ke Hum Yaar Nahin.Chopra next starred opposite Ajay Devgn in Rohit Shetty's comedy Golmaal Again, the fourth installment in the Golmaal film series.
In 2018, she appeared in romantic comedy film Namaste England, alongside Arjun Kapoor. In 2019, Chopra's first appearance was in a brief role in the war film Kesari opposite Akshay Kumar.